Purity levels
Quality designations
Depending on the intended use, it is necessary to adhere to the exact purity or quality specifications when ordering chemicals. The following quality designations of chemicals are arranged in increasing order of purity:
1. crude
2. technical
3. for synthesis
4. pure
5. purest
6. for analysis
7. ultra pure
However, the required purity is not standardized and is determined by the respective manufacturer. The exact specification of a chemical with apparently the same degree of purity therefore depends on the manufacturer.
For fine chemicals that are at least labeled "pure," the type and amount of contamination can be determined from analysis certificates. The minimum content of the main substance and the number of contaminants examined usually depend on the supplier. If you need a high degree of purity, you must check on a case-by-case basis which parameters are important to you and which supplier has the most useful product for your purposes in its range.
Instructions for use
In some catalogs you will also find instructions for the use of the substance. You should not interpret this as a restriction on use. Instructions for use "for microscopy" or "for biochemical purposes" simply state that certain specifications are specifically tailored to these applications.
Pheur at mychem.ch means that this substance is suitable for pharmaceutical purposes.
Components
Read all the information about the chemical you want in the sales catalogue carefully. The quality can also vary due to accompanying substances such as water content or residues from cleaning processes. Abbreviations are often used to describe the chemicals more precisely. In addition, some chemicals have additives added to them to stabilize them for storage and transport (stabilizers, antioxidants, radical inhibitors, etc.).
Chemical purity grades
German and Latin designations from pharmacology are commonly used to describe chemical purity grades:
1. crd.
crudum (= crude), i.e. unpurified grade
2. technical
Technical quality. Products with the purity designation "technical" have a different content.
They are usually produced on a large scale and may have some foreign odor and and color. They are used for general technical purposes.
3. for synthesis
Usually contain small amounts of impurities, but these do not usually interfere with syntheses,
since the product of the synthesis is finally purified and the impurities of the starting material are separated.
Purified and the impurities of the reactant are separated.
4. pur.
purum (= pure), i.e. chemically pure quality.
- minimum content 97 %, unless another content is specified in %.
- correspond to the literature in color and characteristic data except for minor deviations.
- suitable for synthesis and laboratory purposes (also z. Synth.)
- Sensitive products are filled under protective gases.
5. puriss.
purissimum (= pure; of highest purity).
These are substances of particularly pure quality, such that with normal chem. Methods of analysis no foreign substances can be detected with normal
chemical analysis methods:
- Content of at least 99 % or higher (specification).
- correspond in appearance and characteristic
and characteristic data of the relevant literature or deviate from them only to a very small extent.
- are suitable for work with high purity requirements.
- Certificates of analysis are usually supplied with the product or attached to the containers.
- sensitive products are filled under protective gas.
6. p.a.
per analysi (= for analytical purposes)
z. A.
= for analysis
The chemical is so pure that it can be used for analytical analytical methods. In the case of p.a. chemicals,
foreign substances contained therein as well as their content are indicated so that these can be taken into account in analyses and no incorrect analytical
results are obtained due to the chemicals used.
7. Ultrapure
High purity products for specific applications which bear special designations of the respective manufacturers.
All are accompanied by detailed guarantee certificates, which specify maximum contents of many relevant impurities.
Examples
Chemicals for specific applications
- Uvasol®
Solvent for optical spectroscopy
- LiChrosolv®
Solvent for analytical chromatography
- PrepSolv®
Solvent for preparative chromatography
- Pestilyse®
Solvent for residue analysis in environmental, water and food testing
- Suprapur®
Reagent for trace analysis (ppb range)
- SupraSolv ® solvent for residue and environmental analysis in gas chromatography
- Ultrapur ®
Reagent for ultratrace analysis (ppq - ppt- range)
- SeccoSolv® solvents
Dried solvents with extremely low water content
Abbreviations commonly used to describe chemicals
abs. absolute (= purified).
anhydr. anhydricus (= anhydrous)
bidest. double distilled
conc. concentratus (= concentrated)
cryst. or crist. cystallisatum = crystallized
dep. or depur. depuratum (= purified)
dest. destillatum (= distilled)
dil. dilutus (= diluted)
(GC) Content determined by gas chromatography
wt.% glass distilled High purity solvent, which during the distillation process
and until bottling only come into contact with glassware.
cryst. crystallized
praec. Abbreviation for praecipitatum = precipitated
redest. double distilled
resubl. twice sublimed
sicc. siccatum (= dried, anhydrous)
sine H2O without water
sol. or solut. solutus (= dissolved)
stab. stabilized
subl. sublimatum (= sublimed)
subt. subtilis (= fine)
tot. abbreviation for totus = whole, undivided
pharm. pharmaceutical grade, suitable for pharmaceutical purposes
ACS American Chemical Society
DAB German Pharmacopoeia
DAC German Drug Codex
ISO International Organization for Standardization
Ph. Eur. European Pharmacopoeia
Pharmacopoeia quality
In the range of pharmacopoeia-compliant products, two groups can be distinguished, each of which is fully tested and documented according to the required standards:
- Reag. PhEur Analytical Reagents
These are products that are chemically specified according to the methods of pharmacopoeial analysis, i.e. they meet the requirements of the European
Pharmacopoeia. They are therefore suitable for standard pharmacopoeial analysis methods.
- ACC Analytical Reagents
Analytical reagents may also be specified according to the American ACS standard only; they fulfill the requirements of the American Pharmacopoeia.